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RECEPTORS, NOTCH
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DeCS
Descriptor
English
:
Receptors, Notch
Descriptor
Spanish
:
Receptores Notch
Descriptor
Portuguese
:
Receptores Notch
Synonyms
English
:
Notch Proteins
Notch Receptors
Tree Number:
D12.776.543.750.725
D12.776.930.770
Definition
English
:
A
family
of conserved cell surface receptors that contain
EPIDERMAL GROWTH FACTOR
repeats in their extracellular domain and
ANKYRIN
REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the
CELL NUCLEUS
, where they act as
transcription factors.
History Note
English
:
2006(1990)
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
51148
Unique Identifier:
D051880
Occurrence in VHL
:
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